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Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes. Nat Metab. 2019 May;1(5):509-518.

Basile G, Kulkarni RN, Morgan NG. How, When, and Where Do Human β-Cells Regenerate? Curr Diab Rep. 2019 Jun 27;19(8):48.

Chapman SC, Andraska E, Kulkarni RN, Haga LM, Phillips A, Redlinger RE, Hager ES, Madigan MC. Lemierre's Syndrome: An Atypical Presentation. Ann Vasc Surg. 2019 Jun 13. pii: S0890-5096(19)30365-6.

Ng NHJ, Jasmen JB, Lim CS, Lau HH, Krishnan VG, Kadiwala J, Kulkarni RN, Ræder H, Vallier L, Hoon S, Teo AKK. HNF4A Haploinsufficiency in MODY1 Abrogates Liver and Pancreas Differentiation from Patient-Derived Induced Pluripotent Stem Cells. iScience. 2019 Jun 28;16:192-205.

Ji Y, Sun S, Shrestha N, Darragh LB, Shirakawa J, Xing Y, He Y, Carboneau BA, Kim H, An D, Ma M, Oberholzer J, Soleimanpour SA, Gannon M, Liu C, Naji A, Kulkarni RN, Wang Y, Kersten S, Qi L. Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity. Nat Immunol. 2019 Jun;20(6):677-686.

Mezza T, Cinti F, Cefalo CMA, Pontecorvi A, Kulkarni RN, Giaccari A. β-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity. Diabetes. 2019 Jun;68(6):1121-1129.

Dirice E, De Jesus DF, Kahraman S, Basile G, Ng RW, El Ouaamari A, Teo AKK, Bhatt S, Hu J, Kulkarni RN. Human duct cells contribute to β cell compensation in insulin resistance. JCI Insight. 2019 Apr 18;4(8). pii: 99576.

Yi L, Tsai CF, Dirice E, Swensen AC, Chen J, Shi T, Gritsenko MA, Chu RK, Piehowski PD, Smith RD, Rodland KD, Atkinson MA, Mathews CE, Kulkarni RN, Liu T, Qian WJ. Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells. Anal Chem. 2019 Mar 15. 

Jungtrakoon P, Shirakawa J, Buranasupkajorn P, Gupta MK, De Jesus DF, Pezzolesi MG, Panya A, Hastings T, Chanprasert C, Mendonca C, Kulkarni RN, Doria A. Loss-of-Function Mutation in Thiamine Transporter 1 in a Family with Autosomal Dominant Diabetes. Diabetes. 2019 Mar 4. pii: db17082. 

El Ouaamari A, O-Sullivan I, Shirakawa J, Basile G, Zhang W, Roger S, Thomou T, Xu S, Qiang G, Liew CW, Kulkarni RN, Unterman TG. Forkhead box protein O1 (FoxO1) regulates hepatic serine protease inhibitor B1 (serpinB1) expression in a cell non-autonomous fashion. J Biol Chem. 2019 Jan 18;294(3):1059-1069.



Rao TN, Gupta MK, Softic S, Wang LD, Jang YC, Thomou T, Bezy O, Kulkarni RN, Kahn CR, Wagers AJ. Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors. EMBO J. 2018 Nov 16. pii: e100409.

Gupta MK, De Jesus DF, Kahraman S, Valdez IA, Shamsi F, Yi L, Swensen AC, Tseng YH, Qian WJ, Kulkarni RN. Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation. Mol Metab. 2018 Dec;18:153-163.

Iliopoulos-Tsoutsouvas C, Kulkarni RN, Makriyannis A, Nikas SP. Fluorescent probes for G-protein-coupled receptor drug discovery. Expert Opin Drug Discov. 2018 Oct;13(10):933-947.

Jeong DE, Heo S, Han JH, Lee EY, Kulkarni RN, Kim W. Glucose Controls the Expression of Polypyrimidine Tract-Binding Protein 1 via the Insulin Receptor Signaling Pathway in Pancreatic β Cells. Mol Cells. 2018 Oct 31;41(10):909-916.

Kim C, Jeong DE, Heo S, Ji E, Rho JG, Jung M, Ahn S, Kim YJ, Kim YS, Nam SW, Kulkarni RN, Lee KB, Lee EK, Kim W. Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27Kip1 levels and poor prognosis. J Pathol. 2018 Oct;246(2):231-243.

Gannon M, Kulkarni RN, Tse HM, Mauvais-Jarvis F. Sex differences underlying pancreatic islet biology and its dysfunction. Mol Metab. 2018 Sep;15:82-91.

Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Orime K, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y. J Biol Chem. Signaling between pancreatic β cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation. J Biol Chem. 2018 Apr 20;293(16):5934-5946.

Shin H, Han JH, Yoon J, Sim HJ, Park TJ, Yang S, Lee EK, Kulkarni RN, Egan JM, Kim W. Blockade of cannabinoid 1 receptor improves glucose responsiveness in pancreatic beta cells. J Cell Mol Med. 2018 Apr;22(4):2337-2345.

Johansson BB, Fjeld K, El Jellas K, Gravdal A, Dalva M, Tjora E, Ræder H, Kulkarni RN, Johansson S, Njølstad PR, Molven A. The role of the carboxyl ester lipase (CEL) gene in pancreatic disease. Pancreatology. 2018 Jan;18(1):12-19.



Dirice E, Ng RWS, Martinez R, Hu J, Wagner FF, Holson EB, Wagner BK, Kulkarni RN. Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes. J Biol Chem. 2017 Oct 27;292(43):17598-17608.

Johansson BB, Fjeld K, Solheim MH, Shirakawa J, Zhang E, Keindl M, Hu J, Lindqvist A, Døskeland A, Mellgren G, Flatmark T, Njølstad PR, Kulkarni RN, Wierup N, Aukrust I, Bjørkhaug L. Nuclear import of glucokinase in pancreatic beta-cells is mediated by a nuclear localization signal and modulated by SUMOylation. Mol Cell Endocrinol. 2017 Oct 15;454:146-157.

Ghanem SS, Muturi HT, DeAngelis AM, Hu J, Kulkarni RN, Heinrich G, Najjar SM. Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene. Diabetologia. 2017 Sep;60(9):1751-1760.

Kawamori D, Shirakawa J, Liew CW, Hu J, Morioka T, Duttaroy A, Burkey B, Kulkarni  RN. GLP-1 signaling compensates for impaired insulin signaling in mouse β-cell proliferation. Diabetologia. 2017 Aug;60(8):1442-1453.

Patti ME, Goldfine AB, Hu J, Hoem D, Molven A, Goldsmith J, Schwesinger WH, La Rosa S, Folli F, Kulkarni RN. Heterogeneity of proliferative markers in pancreatic β-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass.
Acta Diabetol. 2017 Aug;54(8):737-747.

Shirakawa J, De Jesus DF, Kulkarni RN. Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass. Eur J Clin Nutr. 2017 Mar 15.

Shirakawa J, Fernandez M, Takatani T, El Ouaamari A, Jungtrakoon P, Okawa ER, Zhang W, Yi P, Doria A, Kulkarni RN. Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation. Cell Metab. 2017 Apr 4;25(4):868-882.e5.

Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR. Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. Cell Metab. 2017 Jan 4. pii: S1550-4131(16)30641-6.



Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN. Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep. 2016 Oct 10;6:34969.

Shirakawa J, Kulkarni RN. Novel factors modulating human β-cell proliferation. Diabetes Obes Metab. 2016 Sep;18 Suppl 1:71-7.

Mezza T, Shirakawa J, Martinez R, Hu J, Giaccari A, Kulkarni RN. Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors. J Biol Chem. 2016 Oct 7;291(41):21485-21495.

Takatani T, Shirakawa J, Roe MW, Leech CA, Maier BF, Mirmira RG, Kulkarni RN. IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation. Sci Rep. 2016 Jul 5;6:28177. 

Kahraman S, Okawa ER, Kulkarni RN. Is Transforming Stem Cells to Pancreatic Beta Cells Still the Holy Grail for Type 2 Diabetes? Curr Diab Rep. 2016 Aug;16(8):70.

Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN, O'Neill BT, Kahn CR. Differential Roles of Insulin and IGF-1 Receptors in Adipose Tissue Development and Function. Diabetes. 2016 May 13. pii: db160212. [Epub ahead of print]

Shirakawa J, Kulkarni RN. ERRγ-A New Player in β Cell Maturation. Shirakawa J, Kulkarni RN. Cell Metab. 2016 May 10;23(5):765-7. 

Valdez IA, Dirice E, Gupta MK, Shirakawa J, Teo AK, Kulkarni RN. Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation. Cell Rep. 2016 Apr 19;15(3):460-70. 

Molven A, Hollister-Lock J, Hu J, Martinez R, Njølstad PR, Liew CW, Weir G, Kulkarni RN. The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice. Diabetes. 2016 Jun;65(6):1672-8.

Dhawan S, Dirice E, Kulkarni RN, Bhushan A. Inhibition of TGF-β Signaling Promotes Human Pancreatic β-Cell Replication. Diabetes. 2016 May;65(5):1208-18.

Dirice E, Walpita D, Vetere A, Meier BC, Kahraman S, Hu J, Dančík V, Burns SM, Gilbert TJ, Olson DE, Clemons PA, Kulkarni RN, Wagner BK. Inhibition of DYRK1A Stimulates Human β-Cell Proliferation. Diabetes. 2016 Jun;65(6):1660-71.

Teo AK, Lau HH, Valdez IA, Dirice E, Tjora E, Raeder H, Kulkarni RN. Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia. Stem Cell Reports. 2016 Mar 8;6(3):357-67.

Singhal G, Fisher FM, Chee MJ, Tan TG, El Ouaamari A, Adams AC, Najarian R, Kulkarni RN, Benoist C, Flier JS, Maratos-Flier E. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS One. 2016 Feb 12;11(2):e0148252.

Dirice E, Kulkarni RN. Harnessing immune cells to enhance β-cell mass in type 1 diabetes.J Investig Med. 2016 Jan;64(1):14-20.

El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic β Cell Proliferation. Cell Metab. 2015 Dec 14.



Mezza T, Sorice GP, Conte C, Sun VA, Cefalo CM, Moffa S, Pontecorvi A, Mari A, Kulkarni RN, Giaccari A. Beta cell glucose sensitivity is linked to insulin/glucagon bihormonal cells in non-diabetic humans. J Clin Endocrinol Metab. 2015 Dec 9.

Ghanem SS, Heinrich G, Lester SG, Pfeiffer V, Bhattacharya S, Patel PR, DeAngelis AM, Dai T, Ramakrishnan SK, Smiley ZN, Jung DY, Lee Y, Kitamura T, Ergun S, Kulkarni RN, Kim JK, Giovannucci DR, Najjar SM. Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2). J Biol Chem. 2016 Jan 8;291(2):980-8.

Gupta M, Teo AKK, Rao TN, Bhatt S, Kleinridders A, Shirakawa J, Takatani, T, Hu J, De Jesus DF, Windmueller R, Wagers AJ, Kulkarni  RN*. Excessive cellular proliferation negatively impacts reprogramming efficiency of human fibroblasts. Stem Cells Transl Med 2015 Oct;4(10):1101-1108.

Lee Y-J, Liu C, Liao M, Sukhova GK, Shirakawa J, Abdennour M, Iamarene K, Andre S, Inouye K, Clement K, Kulkarni  RN, Banks AS, Libby P, Shi G-P. Deficiency of FccR1 increases body weight gain but improves glucose tolerance in diet-induced obese mice. Endocrinology 2015 Aug 21:en 20151184.

Teo AKK, Gupta M, Doria A, Kulkarni  RN. Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools. Mol Metab 2015, Jun 20;4(9):593-604.

Bhatt S, Gupta MK, Khamaisi M, Martinez R, Gritsenko MA, Wagner BK, Guye P, Busskamp V, Shirakawa J, Wu G, Liew CW, Clauss TR, Valdez I, El Ouaamari A, Dirice E, Takatani T, Keenan HA, Smith RD, Church G, Weiss R, Wagers AJ, Qian WJ, King GL, Kulkarni RN. Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes. Cell Metab. 2015 Aug 4;22(2):239-252. 

El Ouaamari A, Zhou J, Liew CW, Shirakawa J, Dirice E, Gedeon N, Kahraman S, De Jesus DF, Bhatt S, Kim JS, Clauss TR, Camp DG, Smith RD, Qian WJ, Kulkarni RN. Compensatory Islet Response to Insulin Resistance Revealed by Quantitative Proteomics. J Proteome Res. 2015 Jul 30. [Epub ahead of print].

Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN. Human β-Cell Proliferation and Intracellular Signaling: Part 3. Diabetes. 2015 Jun;64(6):1872-85.

Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL, Russo L, Patel PR, Kaw MK, Raphael CK, Kim AJ, Heinrich G, Lee AD, Kim JK, Kulkarni RN, Philbrick WM, Najjar SM. Forced Hepatic Over-expression of CEACAM1 Curtails Diet-induced Insulin Resistance. Diabetes. 2015 May 13. pii: db141772. [Epub ahead of print]

Rao TN, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN, Serwold T, Pimanda JE, Wagers AJ. High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice. Stem Cell Res. 2015 Feb 18;14(3):307-322. 

Valdez IA, K Teo AK, Kulkarni RN. Cellular stress drives pancreatic plasticity. Sci Transl Med. 2015 Feb 4;7(273):273ps2. Review.



Kulkarni RN, Stewart AF. Summary of the keystone islet workshop (april 2014): the increasing demand for human islet availability in diabetes research. Diabetes. 2014 Dec;63(12):3979-81.

Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ, Stoffers DA. Mol Metab. The Polycomb protein, Bmi1, regulates insulin sensitivity. 2014 Aug 27;3(8):794-802.

Xi Y, Liu S, Bettaieb A, Matsuo K, Matsuo I, Hosein E, Chahed S, Wiede F, Zhang S, Zhang ZY, Kulkarni RN, Tiganis T, Haj FG. Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice. Diabetologia. 2015 Jan;58(1):122-31.

Kahraman S, Dirice E, De Jesus DF, Hu J, Kulkarni RN. Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring. Am J Physiol Endocrinol Metab. 2014 Nov 15;307(10):E906-18.

De Jesus DF, Kulkarni RN. Epigenetic modifiers of islet function and mass. Trends Endocrinol Metab. 2014 Dec;25(12):628-636.

Teo AK, Valdez IA, Dirice E, Kulkarni RN. Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling in Absence of Serum. Stem Cell Reports. 2014 Jun 12;3(1):5-14.

Liu S, Xi Y, Bettaieb A, Matsuo K, Matsuo I, Kulkarni RN, Haj FG. Disruption of protein-tyrosine phosphatase 1B expression in the pancreas affects β-cell function. Endocrinology. 2014 Jun 23:en20132004. [Epub ahead of print]

Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, Urano F, Kulkarni RN. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2319-28.

Hatanaka M, Maier B, Sims EK, Templin AT, Kulkarni RN, Evans-Molina C, Mirmira RG. Palmitate Induces mRNA Translation and Increases ER Protein Load in Islet β Cells via Activation of the Mammalian Target of Rapamycin Pathway. Diabetes. 2014 May 16. pii: DB_140105. [Epub ahead of print]

Mezza T, Kulkarni RN. The regulation of pre- and post-maturational plasticity of mammalian islet cell mass. Diabetologia. 2014 Jul;57(7):1291-303. 

Bernal-Mizrachi E, Kulkarni RN, Scott DK, Mauvais-Jarvis F, Stewart AF, Garcia-Ocaña A. Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes. 2014 Mar;63(3):819-31. 

Kilic G, Alvarez-Mercado AI, Zarrouki B, Opland D, Liew CW, Alonso LC, Myers MG Jr, Jonas JC, Poitout V, Kulkarni RN, Mauvais-Jarvis F.The Islet Estrogen Receptor-α Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes. PLoS One. 2014 Feb 3;9(2):e87941

Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR. p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1192-7

Dirice E, Kahraman S, Jiang W, El Ouaamari A, De Jesus D, Teo A, Hu J, Kawamori D, Gaglia J, Mathis D, Kulkarni RN. Soluble factors secreted by T-cells promote β-cell proliferation. Diabetes 2014 Jan;63(1):188-202 

Ræder H, McAllister F, Tjora E, Bhatt S, Haldorsen I, Hu J, Willems SM, Vesterhus M, El Ouaamari A, Liu M, Ræder M, Immervoll H, Hoem D, Dimcevski G, Njølstad P, Molven A, Gygi S, Kulkarni RN. Carboxyl-ester lipase Maturity-Onset Diabetes of the Young is Associated with Development of Pancreatic Cysts and Upregulated MAPK Signaling in Secretin-stimulated duodenal fluid. Diabetes 2014 Jan;63(1):259-269


Mezza T, Muscogiuri G, Sorice, G.P., Clemente G, Hu J, Pontecorvi A, Holst J, Giaccari A, Kulkarni, RN. Insulin resistance alters islet morphology in non-diabetic humans. Diabetes 2013.

Teo AK, Wagers AJ, Kulkarni RN. New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism. Cell Metab.  2013 Dec 3;18(6):775-91.

Negahdar M, Aukrust I,  Molnes J, Solheim MH,  Johansson BB, Sagen JV,  Dahl-Jørgensen K; Kulkarni RN, Søvik O,  Flatmark T,  Bjørkhaug L, Njolstad P. GCK-MODY diabetes as a protein misfolding disease: The mutation R275C promotes protein misfolding, self-association and cellular degradation. Molecular and Cellular Endocrinology. 2013 Aug 31. doi:pii: S0303-7207(13)00357-2

Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ. Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun. 2013;4:1871. 

Ræder H, Vesterhus M, El Ouaamari A, Paulo JA, McAllister FE, Liew CW, Hu J, Kawamori D, Molven A, Gygi SP, Njølstad PR, Kahn CR, Kulkarni RN. Absence of Diabetes and Pancreatic Exocrine Dysfunction in a Transgenic Model of Carboxyl-Ester Lipase-MODY (Maturity-Onset Diabetes of the Young). PLoS One. 2013;8(4):e60229.

Akiyama M, Liew CW, Lu S, Hu J, Martinez R, Hambro B, Kennedy RT, Kulkarni RN. X-box binding protein 1 is essential for insulin regulation of pancreatic alpha cell function. Diabetes. 2013 Jul;62(7):2439-49.

El Ouaamari A., Kawamori D., Dirice E., Liew C.W., Shadrach J.L., Hu J., Katsuta H., Hollister-Lock J., Qian W.J., Wagers A.J., Kulkarni RN. Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states. Cell Rep. 2013 Feb 21;3(2):401-10. 

Teo A.K., Windmueller R., Johansson B.B., Dirice E., Njosltad P., Tjora E., Raeder H., Kulkarni R.N. Derivation of human induced-pluripotent stem cells from patients with maturity onset diabetes of the young. J Biol Chem. 2013 Feb 22;288(8):5353-6. 

Aukrust I., Bjorkhaug L., Molnes, J., Haas W., Gygi S., Sovik O, Flatmark T., Kulkarni R.N., Njolstad P.  SUMOylation of pancreatic glucokinase regulates its cellular stability and activity. J Biol Chem. 2013 Feb 22;288(8):5951-62. 

Liew, C.W., Boucher, J., Cheong, J.K., Vernochet, C., Mallol, C., Townsend, K., Langin, D., Kawamori. D,, Hu. J, Tseng, Y-H, Hellerstein, M.K., Farmer, S.R., Goodyear, L., Doria, A., Bluher, M., Hsu, SI-H, Kulkarni, R.N.*. Ablation of TRIP-Br2, a novel regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Medicine. 2013 Feb;19(2):217-26. 



Teo, A.K., Kulkarni, R.N. (2012)Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor. EMBO J. 2012 Oct 17;31(20):3956-7.

Negahdar, M., Aukrust, I., Johansson, B.B., Molnes, J., Molven, A., Matschinsky, F.M., Sovik, O., Kulkarni, R.N., Flatmark, T., Njolstad, P.R., and Bjokhaug, L. (2012) GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation. Biochimica et Biophysica Acta. Nov;1822(11):1705-15.

Welters, H., El Ouaamari, A., Kawamori, D., Meyer, J., Hu, J., Smith, D., and Kulkarni, R. N. (2012). Rosiglitazone promotes PPARgamma dependent and independent alterations in gene expression in mouse islets. Endocrinology. Oct;153(10):4593-9.

Kulkarni, RN. Identifying biomarkers of subclinical diabetes. (2012) Diabetes Aug 61(8):1925-6  

Kulkarni, R.N., Bernal-Mizrachi E., Garcia-Ocana A., Stewart AF. (2012) Human beta cell proliferation and intracellular signaling: driving in the dark without a roadmap. Diabetes. Sep;61(9):2205-13.

Goldfine A.B., Kulkarni, R.N. (2012) Insulin modulation of beta cell function: a translational journey from the bench to the bedside. Diabetes Obesity Metab. 2012 Oct;14 Suppl 3:152-60.

Morioka T., Dishinger J.F., Reid K.R., Liew C.W., Zhang T., Inaba M., Kennedy R.T., Kulkarni R.N. (2012). Enhanced GLP-1- and Sulfonylurea-Induced Insulin Secretion in Islets Lacking Leptin Signaling. Mol Endocrinol. Jun;26(6):967-76

Kim W., Lao Q., Shin Y-K., Carlson O.D., Lee E.K., Gorospe M., Kulkarni R.N., Egan J.M. (2012). Cannabinoids induce pancreatic beta-cell death by directly inhibiting insulin receptor activation. Science Signaling. Mar 20;5(216):ra23

Kebede M., Ferdaoussi M., Mancini A., Alquier T., Kulkarni R.N., Walker M.D., Poitout V. (2012). Glucose activates GPR40 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1. Proc Natl Acad Sci. Feb 14;109(7):2376-81.

Lee E.K., Kim W., Tominaga K., Martindale J.L., Yang X., Subaran S.S., Carlson O.D., Kulkarni R.N., Akamatsu W., Okano H., Egan J.M., Gorospe M. (2012). RNA-binding protein HuD controls insulin translation. Molecular Cell. Mar 30;45(6):826-35.

Halperin, F., Lopez, X., Manning, R., Kahn, C.R., Kulkarni, R.N., Goldfine, A.B. (2012). Insulin augmentation of glucose stimulated insulin secretion is impaired in insulin resistant humans. Diabetes. Feb;61(2):301-9.

Galkina E, Butcher M, Keller SR, Goff M, Bruce A, Pei H, Sarembock IJ, Sanders JM, Nagelin MH, Srinivasan S, Kulkarni RN, Hedrick CC, Lattanzio FA, Dobrian AD, Nadler JL, Ley K. (2012) Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arteriosclerosis, Thrombosis and Vascular Biology. Feb;32(2):247-56. Epub 2011 Dec 22.



Folli F, Okada T., Perego, C., Gunton, J., Liew, C.W., Akiyama M, D' Amico A, La Rosa S, Placidi C, Lupi R, Marchetti P, Sesti G, Hellerstein M, Perego L, Kulkarni RN. (2011) Altered insulin receptor signalling and b-cell cycle dynamics in type 2 diabetes mellitus. PLoS One. 6(11):e28050

Rowland, K.J., Trivedi, S., Lee, D., Wan, K., Kulkarni, R.N.,Holzenberger, M., Brubaker, P.L. (2011) Loss of Glucagon-Like Peptide-2 induced Proliferation following Intestinal Epithelial Insulin-Like Growth Factor-1 Receptor Deletion. Gastroenterology,141(6):2166-2175

Lopez, X., Cypress, A., Manning, R., O'Shea, S., Kulkarni, R.N., Goldfine, A.B. (2011) Exogenous insulin enhances glucose-stimulated insulin secretion in healthy humans independent of changes in free fatty acids.  J Clin Endocrinol Metab. Dec;96(12):3811-21.

Dirice E, Kulkarni RN. Pathways regulating b-cell regeneration in type 1, type 2 and gestational diabetes. In Kulkarni R.N., ed. Islet Growth Factors. Landes Bioscience, pp 1-22, 2011.

Morioka T, Kulkarni RN. Pancreatic islet b-cell failure in obesity. Chapter 11; In Metabolic basis of obesity, ed. Ahima R. Springer Science (in press), 2011.

Spiegel, A., Carter-Su C., Taylor, S.I., Kulkarni, R.,N. Mechanism of action of hormones that act at the cell surface. In Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology. 12th edition. Saunders, 2011

Reiner, T., Thurber, G., Gaglia, J., Vinegoni, C., Liew, C.W., Upadhyay, R., Kohler, R.H., Li, L., Kulkarni, R.N., Benoist, C., Mathis, D., Weissleder, R. (2011) Accurate measurement of pancreatic islet {beta}-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci 108(31):12815-20

Lin,W., Cao, J., Liu, J., Beshiri, M, Fujiwara, Y., Francis, J.M., Cherniack, A., Geisen, C., Blair, L.P., Zou, M., Shen, X., Kawamori, D., Liu, Z., Grisanzio, C., Watanabe, H., Minamishima, Y., Zhang, Q., Kulkarni, R.N., Signoretti, S., Rodig, S.J., Bronson, R.T., Orkin, S.H., Tuck, D.P., Benevolenskaya, E., Meyerson, M., Kaelin, W.G., Yan, Q. (2011) Loss of the RBP2 histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci 108(33):13379-86.

Kawamori, D., Akiyama, M., Hu, J., Hambro, B., Kulkarni, R.N. (2011) Growth factor signaling in the regulation of a-cell fate. Diabetes Obes Metab 13, Suppl 1:21-30

Zhou, J.Y., Dann, G.P., Liew, C.W., Smith, R.D., Kulkarni, R.N., Qian, W.J. (2011) Unraveling Pancreatic Islet Biology by Quantitative Proteomics. Expert Reviews of Proteomics 8(4):495-504

Kawamori, D., Kulkarni, R.,N. Molecular mechanism for the intra-islet regulation of glucagon secretion. "Hypoglycemia / Book 2" 2011 InTech (ISBN 979-953-307-245-5)

Kim, W., Doyle, M. E., Liu, Z., Lao, Q., Shin, Y-K., Carlson, O. D., Kim, H-S., Thomas, S., Napora, J. K., Lee, E. K., Moaddel, R., Wang, Y., Maudsley, S., Martin, B., Kulkarni, R. N., and Egan, J. M. (2011) Cannabinoids inhibit insulin receptor signaling in pancreatic beta cells. Diabetes 60(4):1198-209

Hinault, C., Kawamori, D., Liew, C. W., Maier B., Hu, J., Keller, S. R., Mirmira, R. G., Scrable, H. and Kulkarni, R. N. (2011) Delta 40 isoform of p53 controls b-cell proliferation and glucose homeostasis in mice. Diabetes 60(4):1210-22                                 



Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, Kahn CR, Kasai H, Cantley LC, Kadowaki T. (2010) Class IA phosphatidylinositol 3-kinase in pancreatic beta-cells controls insulin secretion by multiple mechanisms. Cell Metab. 12(6):619-32.

Kulkarni R. N. (2010) GIP: No Longer the Neglected Incretin Twin? Sci Transl Med. 2(49):49ps47

Vesterhus M., Raeder H., Kurpad A. J., Kawamori D., Molven A., Kulkarni R. N., Kahn C. R., Njolstad P. R. (2010) Pancreatic Function in Carboxyl-Ester Lipase Knockout Mice. Pancreatology. 10(4):467-476.

Reiner, T., Kohler, R. H., Liew, C. W., Hill, J., Gaglia, J., Kulkarni, R. N., and Weissleder, R. (2010) Near-Infrared Fluorescent Probe for Imaging of Pancreatic beta-cells. Bioconjugate Chem 21(7):1362-8.

Liew, C. W., Bochenski, J., Kawamori, D., Hu, J., Leech, C. A., Wanic, K., Malecki, M., Warram, J. H., Qi, L., Krolewski, A. J., and Kulkarni, R. N. (2010) The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta-cells. J Clin Invest 120(8):2876-88.

Cheng, K., Ho, K., Stokes, R., Scott, C., Mei Lau, S., Hawthorne, W. J., Oonnell, P. J., Loudovaris, T., Kay, T. W., Kulkarni, R. N., Okada, T., Wang, X., Yim, S., Shah, Y., Grey, S. T., Biankin, A. V., Kench, J. G., Laybutt, D. R., Gonzalez, F. J., Kahn, C. R., and Gunton, J. E. (2010) Hypoxia-inducible factor-1alpha regulates beta-cell function in mice and in human islets. J Clin Invest 120(6): 2171-83.

Kawamori, D., Welters, H. J., and Kulkarni, R. N. (2010) Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. The Islets of Langerhans, Advances in Experimental Medicine and Biology 654: 421-45. Review

Bouche, C., Lopez, X.,Fleischman, A., Cypess, A. M., O?hea, S., Stefanovski, D., Bergman, R. N., Rogatsky, E., Stein, D. T., Kahn, C. R., Kulkarni, R. N., and Goldfine, A. B. (2010) Insulin enhances glucose-stimulated insulin secretion in healthy humans. Proc Natl Acad Sci USA 107(10): 4770-5.

Cornu, M., Modi, H., Kawamori, D., Kulkarni, R. N., Joffraud, M., and Thorens, B. (2010) Glucagon-like peptide-1 (GLP-1) increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor (IGF-1R) expression. J Biol Chem 285(14):10538-45.

Georgia, S., Hinault, C., Kawamori, D., Hu, J., Meyer, J., Kanji, M., Bhushan, A., and Kulkarni, R. N. (2010) Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents. Diabetes 59(4):987-96.

Robertson, S., Ishida-Takahashi, R., Tawara, I., Hu, J., Patterson, C. M., Jones, J. C., Kulkarni, R. N., and Myers, M. G. Jr. (2010) Insufficiency of Jak2-autonomous leptin receptor signals for most physiologic leptin actions. Diabetes 59(4):782-90.

Zhang, Z., Liew, C. W., Handy, D. E., Zhang, Y., Leoold, J. A., Hu, J., Guo, L., Loscalzo, J., Kulkarni, R. N., and Stanton, R. C. (2010) High glucose inhibits glucose-6-phosphate dehydrogenase leading to increased oxidative stress and beta cell apoptosis. FASEB J 24(5):1497-505.



Liu, S., Okada, T., Assmann, A., Soto, J., Liew, C. W., Bugger, H., Shirihai, O., Abel, E. D., and Kulkarni, R. N. (2009) Insulin signaling regulates mitochondrial function in pancreatic beta-cells. PLoS One 24;4(11): e7983

Kawamori, D. and Kulkarni, R. N. (2009) Insulin modulation of glucagon secretion: The role of insulin and other factors in the regulation of glucagon secretion. Islets 1(3):276-9

Zhou, J. Y., Petritis, B. O., Petritis, K., Norbeck, A. D., Weitz, K. K., Moore, R. J., Camp, D. G., Kulkarni, R. N., Smith, R. D., and Qian, W. J. (2009) Mouse-Specific Tandem IgY7-SuperMix Immunoaffinity Separations for Improved LC-MS/MS Coverage of the Plasma Proteome. J Proteome Res. 8: 5387-95.

Liew, C. W., Holman, A., and Kulkarni, R. N. (2009) The roles of telomeres and telomerase in beta-cell regeneration. Diabetes Obes Metab 11, Suppl 4:21-9.

Borowiec, M., Liew, C. W., Thompson, R., Boonyasrisawat, W., Hu, J., Mlynarski, W. M., El Khattabi, I., Kim, S. H., Marselli, L., Rich, S. S., Krolewski, A. S., Bonner-Weir, S., Sharma, A., Sale, M., Mychaleckyj, J. C., Kulkarni, R. N., and Doria, A. (2009) Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 106, 14460-5.

Kulkarni, R. N. (2009) Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 150, 2994-6

Kawamori, D., Kurpad, A. J., Hu, J., Liew, C. W., Shih, J. L., Ford, E. L., Herrera, P. L., Polonsky, K. S., McGuinness, O. P., and Kulkarni, R. N. (2009) Insulin signaling in alpha-cells modulates glucagon secretion in vivo. Cell Metabolism Apr;9(4):350-61.

Assmann, A., Ueki, K., Winnay, J. N., and Kulkarni, R. N. (2009) Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate-2. Mol Cell Biol 29:3219-28

Torii, S., Saito, N., Kawano, A., Hou, N., Ueki, K., Kulkarni, R. N., Takeuchi, T. (2009) Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta cell growth. Diabetes 58:682-92

Assmann, A., Hinault, C., and Kulkarni, R. N. (2009) Growth factor control of pancreatic islet regeneration and function. Pediatric Diabetes 10:14-32.

Hisanaga, E., Nagasawa, M., Ueki, K., Kulkarni, R. N.,  Mori, M. M. and Kojima. I. (2009) Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells. Diabetes 58:174-84



Welters, H. J. and Kulkarni, R. N. (2008) Wnt signaling and type 2 diabetes. Trends Endocrinol Metab 19:349-55.

Tseng, Y-H., Kokkotou, E., Huang, T. L., Taniguchi, C. M., Tran, T. T., Suzuki, R., Schulz, T. J.,  Espinoza, D. O., Winnay, J. N., Yamomoto, Y., Ahrens, M. J., Dudley, A. T., Norris, A. W., Kulkarni, R. N., and Kahn, C. R (2008) Novel role of bone morphogenetic protein-7 in brown adipogenesis and energy expenditure. Nature 454, 1000-4.

Deangelis, A. M., Heinrich, G., Bowman, T. A., Patel, P. R., Dai, T., Lee, S-J., Hong, E-G., Jung, D-Y., Assmann, A., Kulkarni, R. N., Beauchemin, N., Kim, J. K., and Najjar, S. M. (2008) CEACAM1: A Link Between Insulin and Lipid Metabolism. Diabetes 57, 2296-303.

Hinault, C., Hu, J., Maier, B. F., Mirmira, R. G., and Kulkarni, R. N. (2008) Differential expression of cell cycle proteins during aging of pancreatic islet cells. Diabet Obes Metab 10, 136-46.

Petyuk, V., Qian, W-J., Hinault, C., Gritsenko, M., Singhal, M., Monroe, M., Camp, D., Kulkarni, R. N. *, and Smith, R. D.* (2008) Characterization of the mouse pancreatic islet proteome and comparative analysis with other mouse tissues. J Proteome Res 7, 3114-26. (*corresponding)


Page, K., DeJardin, S., Kahn, C. R., Kulkarni, R. N., Herold, K., and Inzucchi, S. (2007) Type B insulin resistance syndrome in a hospitalized patient with diabetes mellitus, responsive to immunotherapy. Nat Clin Pract Endocrinol Med. 3, 835-40

Handschin C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Liu, F., Maratos-Flier, E., Mooth, V. K., Kim, Y., Kulkarni, R. N., Shulman, G. I., and Spiegelman, B. M. (2007) Abnormal glucose homeostasis in skeletal muscle-specific PGC-1 knockout mice through skeletal muscle-pancreatic b-cell cross-talk. J Clin Invest. 117, 3463-74

Morioka, T., Asilmaz, E., Hu, J., Dishinger, J. F., Kurpad, A. J., Elias, C. F., Li, H., Elmquist, J. K., Kennedy, R. T., and Kulkarni, R. N. (2007) Disruption of leptin receptor expression in the pancreas directly impacts islet growth and function. J Clin Invest. 117, 2860-8

Matsumura, K., Chang, BH-J., Fujiyama, M., Chen, W., Kulkarni, R. N., Eguchi, Y., Kimura, H., Kojima, H., and Chan, L. (2007) Aquaporin is a beta-cell protein and regulator of intra-islet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 27, 6026-37

Kulkarni, R. N. and Kahn, C. R. (2007) Ephs and ephrins keep pancreatic Beta cells connected. Cell. 129, 241-3.

Okada, T., Liew, C. W., Hu, J., Hinault, C., Michael, M. D., Krutzfeldt, J., Yin, C., Holzenberger, M., Stoffel, M., and Kulkarni, R. N. (2007) Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance. Proc Natl Acad Sci U S A. 104, 8977-82.

Pissios, P., Ozcan, U., Kokkotou, E., Okada, T., Liew, C. W., Liu, S., Peters, J. N., Dahlgren, G., Karamchandani, J., Kudva, Y. C., Kurpad, A. J., Kennedy, R. T., Maratos-Flier, E., and Kulkarni, R. N. (2007) Melanin concentrating hormone is a novel regulator of islet function and growth. Diabetes. 56, 311-319.



Ueki, K., Okada, T., Hu, J., Liew, C. W., Assmann, A., Dahlgren, G. M., Peters, J. L., Shackman, J. G., Zhang, M., Artner, I., Satin, L. S., Stein, R., Holzenberger, M., Kennedy, R. T., Kahn, C. R., and Kulkarni, R. N. (2006) Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes. Nat Genet 38, 583-588.

Qi, L., Heredia, J. E., Altarejos, J. Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I. X., Liew, C. W., Kulkarni, R. N., Bain, J., Newgard, C., Nelson, M., Evans, R. M., Yates, J., and Montminy, M. (2006) TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312, 1763-1766.

Neubauer, N., and Kulkarni, R. N. (2006) Molecular approaches to study control of glucose homeostasis. Ilar J 47, 199-211.

Koh, H. J., Arnolds, D. E., Fujii, N., Tran, T. T., Rogers, M. J., Jessen, N., Li, Y., Liew, C. W., Ho, R. C., Hirshman, M. F., Kulkarni, R. N., Kahn, C. R., and Goodyear, L. J. (2006) Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol 26, 8217-8227.

He, Z., Opland, D. M., Way, K. J., Ueki, K., Bodyak, N., Kang, P. M., Izumo, S., Kulkarni, R. N., Wang, B., Liao, R., Kahn, C. R., and King, G. L. (2006) Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol 26, 787-793.



Kulkarni, R. N. (2005) New insights into the roles of insulin/IGF-I in the development and maintenance of beta-cell mass. Rev Endocr Metab Disord 6, 199-210.

Hennige, A. M., Ozcan, U., Okada, T., Jhala, U. S., Schubert, M., White, M. F., and Kulkarni, R. N. (2005) Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. Am J Physiol Endocrinol Metab 289, E337-346.

Gunton, J. E., Kulkarni, R. N., Yim, S., Okada, T., Hawthorne, W. J., Tseng, Y. H., Roberson, R. S., Ricordi, C., O'Connell, P. J., Gonzalez, F. J., and Kahn, C. R. (2005) Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122, 337-349.

Bates, S. H., Kulkarni, R. N., Seifert, M., and Myers, M. G., Jr. (2005) Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis. Cell Metab 1, 169-178.



Otani, K., Kulkarni, R. N., Baldwin, A. C., Krutzfeldt, J., Ueki, K., Stoffel, M., Kahn, C. R., and Polonsky, K. S. (2004) Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 286, E41-49.

Kulkarni, R. N. (2004) The islet beta-cell. Int J Biochem Cell Biol 36, 365-371.

Kulkarni, R. N., and Kahn, C. R. (2004) Molecular biology. HNFs--linking the liver and pancreatic islets in diabetes. Science 303, 1311-1312.

Kulkarni, R. N., Roper, M. G., Dahlgren, G., Shih, D. Q., Kauri, L. M., Peters, J. L., Stoffel, M., and Kennedy, R. T. (2004) Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. Diabetes 53, 1517-1525.

Kulkarni, R. N., Jhala, U. S., Winnay, J. N., Krajewski, S., Montminy, M., and Kahn, C. R. (2004) PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. J Clin Invest 114, 828-836.

Goren, H. J., Kulkarni, R. N., and Kahn, C. R. (2004) Glucose homeostasis and tissue transcript content of insulin signaling intermediates in four inbred strains of mice: C57BL/6, C57BLKS/6, DBA/2, and 129X1. Endocrinology 145, 3307-3323.



Rosen, E. D., Kulkarni, R. N., Sarraf, P., Ozcan, U., Okada, T., Hsu, C. H., Eisenman, D., Magnuson, M. A., Gonzalez, F. J., Kahn, C. R., and Spiegelman, B. M. (2003) Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Mol Cell Biol 23, 7222-7229.

Kulkarni, R. N., and Zisman, A. (2003) Lessons for human diabetes from experimental mouse models. Curr Diab Rep 3, 168-175.

Kulkarni, R. N., Almind, K., Goren, H. J., Winnay, J. N., Ueki, K., Okada, T., and Kahn, C. R. (2003) Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes 52, 1528-1534.

Jiang, Z. Y., He, Z., King, B. L., Kuroki, T., Opland, D. M., Suzuma, K., Suzuma, I., Ueki, K., Kulkarni, R. N., Kahn, C. R., and King, G. L. (2003) Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J Biol Chem 278, 31964-31971.

Jhala, U. S., Canettieri, G., Screaton, R. A., Kulkarni, R. N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M., and Montminy, M. (2003) cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev 17, 1575-1580.

Hennige, A. M., Burks, D. J., Ozcan, U., Kulkarni, R. N., Ye, J., Park, S., Schubert, M., Fisher, T. L., Dow, M. A., Leshan, R., Zakaria, M., Mossa-Basha, M., and White, M. F. (2003) Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest 112, 1521-1532.

Du, K., Herzig, S., Kulkarni, R. N., and Montminy, M. (2003) TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300, 1574-1577.

Almind, K., Kulkarni, R. N., Lannon, S. M., and Kahn, C. R. (2003) Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 52, 1535-1543.



Roper, M. G., Qian, W. J., Zhang, B. B., Kulkarni, R. N., Kahn, C. R., and Kennedy, R. T. (2002) Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells. Diabetes 51 Suppl 1, S43-49.

Mauvais-Jarvis, F., Kulkarni, R. N., and Kahn, C. R. (2002) Knockout models are useful tools to dissect the pathophysiology and genetics of insulin resistance. Clin Endocrinol (Oxf) 57, 1-9.

Laustsen, P. G., Michael, M. D., Crute, B. E., Cohen, S. E., Ueki, K., Kulkarni, R. N., Keller, S. R., Lienhard, G. E., and Kahn, C. R. (2002) Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev 16, 3213-3222.

Kulkarni, R. N., Holzenberger, M., Shih, D. Q., Ozcan, U., Stoffel, M., Magnuson, M. A., and Kahn, C. R. (2002) beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet 31, 111-115.

Kulkarni, R. N. (2002) Receptors for insulin and insulin-like growth factor-1 and insulin receptor substrate-1 mediate pathways that regulate islet function. Biochem Soc Trans 30, 317-322.

Kulkarni, R. N., and Okada, T. (2002) Tissue-specific targeting of the insulin receptor gene. Endocrine 19, 257-266.



Leibiger, B., Leibiger, I. B., Moede, T., Kemper, S., Kulkarni, R. N., Kahn, C. R., de Vargas, L. M., and Berggren, P. O. (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 7, 559-570.

Flier, S. N., Kulkarni, R. N., and Kahn, C. R. (2001) Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc Natl Acad Sci U S A 98, 7475-7480.



Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., and Kahn, C. R. (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 6, 87-97.

Mauvais-Jarvis, F., Virkamaki, A., Michael, M. D., Winnay, J. N., Zisman, A., Kulkarni, R. N., and Kahn, C. R. (2000) A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes. Diabetes 49, 2126-2134.

Kulkarni, R. N., Wang, Z. L., Wang, R. M., Smith, D. M., Ghatei, M. A., and Bloom, S. R. (2000) Glibenclamide but not other sulphonylureas stimulates release of neuropeptide Y from perifused rat islets and hamster insulinoma cells. J Endocrinol 165, 509-518.

Kahn, C. R., Bruning, J. C., Michael, M. D., and Kulkarni, R. N. (2000) Knockout mice challenge our concepts of glucose homeostasis and the pathogenesis of diabetes mellitus. J Pediatr Endocrinol Metab 13 Suppl 6, 1377-1384.

Aspinwall, C. A., Qian, W. J., Roper, M. G., Kulkarni, R. N., Kahn, C. R., and Kennedy, R. T. (2000) Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells. J Biol Chem 275, 22331-22338.



Kulkarni, R. N., Bruning, J. C., Winnay, J. N., Postic, C., Magnuson, M. A., and Kahn, C. R. (1999) Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell 96, 329-339.

Kulkarni, R. N., Winnay, J. N., Daniels, M., Bruning, J. C., Flier, S. N., Hanahan, D., and Kahn, C. R. (1999) Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. J Clin Invest 104, R69-75.


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